Role of C-Reactive Protein in Atherogenesis : Can the Apolipoprotein E Knockout Mouse
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چکیده
Black, David Samols, Michael Torzewski, Karl J. Lackner, Matthias Husmann, Maria Blettner Kurt Reifenberg, Hans-Anton Lehr, Daniela Baskal, Elena Wiese, Stephan C. Schaefer, Steven Provide the Answer? Role of C-Reactive Protein in Atherogenesis : Can the Apolipoprotein E Knockout Mouse Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2005 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000171983.95612.9
منابع مشابه
Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?
OBJECTIVE Human C-reactive protein (CRP) was reported to accelerate atherosclerotic lesion development in male but not in female apolipoprotein E (apoE) knockout mice. Here, mice expressing rabbit CRP (rbCRP) were crossbred onto apoE knockout animals, and the effect on atherogenesis was studied. METHODS AND RESULTS Hemolytic complement activity could not be detected in apoE knockout mice. Fur...
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Dietary salt intake is a major determinant of the activation state of renin-angiotensin-aldosterone system. Given the important role of the renin-angiotensin-aldosterone system in plaque accumulation, we investigated its role in the development of atherogenesis associated with sodium intake in apolipoprotein E knockout mice. Six-weeks of a low-salt diet (containing 0.03% sodium) resulted in a 4...
متن کاملRenin-Angiotensin-System Activation of the Renin-Angiotensin System Mediates the Effects of Dietary Salt Intake on Atherogenesis in the Apolipoprotein E Knockout Mouse
Dietary salt intake is a major determinant of the activation state of renin-angiotensin-aldosterone system. Given the important role of the renin-angiotensin-aldosterone system in plaque accumulation, we investigated its role in the development of atherogenesis associated with sodium intake in apolipoprotein E knockout mice. Six-weeks of a low-salt diet (containing 0.03% sodium) resulted in a 4...
متن کاملDietary cholesterol plays a role in CD36-mediated atherogenesis in LDLR-knockout mice.
OBJECTIVE CD36 has been shown to play a role in atherosclerosis in the apolipoprotein E-knockout (apoE(o)) mouse. We observed no difference in aortic lesion area between Western diet (WD)-fed LDLR(o) and LDLR(o)/CD36(o) mice. The objective was to understand the mechanism of CD36-dependent atherogenesis. METHODS AND RESULTS ApoE(o) mice transplanted with bone marrow from LDLR(o)/CD36(o) mice h...
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